Retatrutide Dosage Calculator

Calculate appropriate Retatrutide dosage based on patient weight, treatment goals, and clinical factors. Always consult with a healthcare professional before use.

Patient Weight (kg) Enter patient weight in kilograms

Current BMI Body Mass Index (weight in kg ÷ height in m²)

Treatment Phase

Previous Dose Tolerance

Number of Obesity-Related Comorbidities: 0 e.g., hypertension, type 2 diabetes, dyslipidemia, sleep apnea

Renal Impairment Present

Quick Examples:

How to Use This Calculator

Enter the patient's weight in kilograms
Input the patient's current Body Mass Index (BMI)
Select the appropriate treatment phase
Indicate tolerance to previous doses if applicable
Adjust the slider for number of obesity-related comorbidities
Toggle renal impairment if present, then click Calculate

Dosage Calculation Guidelines

Base Dose + (Weight Factor × 0.1mg) + (BMI Factor × 0.05mg) + (Comorbidity Factor × 0.08mg)

Where:

Base Dose = Phase-dependent starting point (2mg initial, 4mg escalation, 8mg maintenance)
Weight Factor = (Weight in kg - 70) / 10
BMI Factor = (BMI - 25) / 5
Comorbidity Factor = Number of comorbidities (max 5)
Adjustments made for tolerance and renal impairment

Example Calculation

Patient Scenario:

A 45-year-old patient with obesity, hypertension, and prediabetes needs initial Retatrutide therapy.

Given:

Weight = 95kg
BMI = 32.4
Treatment Phase = Initial
Comorbidities = 2 (hypertension, prediabetes)
No renal impairment

Calculation:

Base Dose (Initial) = 2mg

Weight Factor = (95 - 70)/10 = 2.5 × 0.1mg = 0.25mg

BMI Factor = (32.4 - 25)/5 = 1.48 × 0.05mg = 0.074mg

Comorbidity Factor = 2 × 0.08mg = 0.16mg

Result: 2 + 0.25 + 0.074 + 0.16 = 2.484mg → Rounded to 2.5mg weekly

Why Proper Dosing Matters

Clinical Benefits

Optimizes weight loss efficacy while minimizing side effects
Reduces risk of gastrointestinal adverse events
Allows for personalized treatment based on individual factors

Safety Considerations

Prevents excessive dosing in sensitive populations
Accounts for renal function impairment
Considers individual tolerance patterns

Common Mistakes & Tips

Retatrutide should be initiated at the lowest recommended dose and gradually increased. Starting with doses that are too high significantly increases the risk of gastrointestinal side effects and may lead to treatment discontinuation.

Patients with renal impairment may require dose adjustments as Retatrutide is primarily eliminated through renal pathways. Failure to adjust dosing can lead to drug accumulation and increased adverse effects.

Frequently Asked Questions

Dosage adjustments typically occur every 4 weeks during the escalation phase, based on tolerance and efficacy. During maintenance therapy, doses are generally stable but may be adjusted if weight loss plateaus or if side effects occur.

The most common side effects include nausea, vomiting, diarrhea, constipation, and abdominal pain. These are typically dose-dependent and often diminish over time. Starting with a lower dose and gradual escalation can help minimize these effects.

Yes, Retatrutide can be used in patients with type 2 diabetes, but additional considerations are needed. These patients may require more gradual dose escalation and closer monitoring of glycemic control, as Retatrutide has glucose-lowering effects that may necessitate adjustment of other diabetes medications.

References & Disclaimer

Medical Disclaimer

This calculator provides estimated dosing information for educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication regimen.

References

Phase 2 Trial of Retatrutide in Obesity - New England Journal of Medicine study on efficacy and dosing
FDA Approval Information - Official FDA prescribing information and guidelines
Clinical Pharmacology of Retatrutide - Comprehensive review of mechanism of action and pharmacokinetics

Accuracy Notice

This calculator provides estimates based on clinical trial data and general prescribing guidelines. Individual patient factors may necessitate adjustments not captured in this algorithm. Always verify dosing with the most current prescribing information and consider individual patient characteristics.

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About the Author

Kumaravel Madhavan

Web developer and data researcher creating accurate, easy-to-use calculators across health, finance, education, and construction and more. Works with subject-matter experts to ensure formulas meet trusted standards like WHO, NIH, and ISO.

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health medical-clinical-calculators retatrutide dosage medical body weight

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